1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-ylmethanol → 1-(4'-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

1-(4′-Fluorophenyl)-1,3-dihydroisobenzofuran-5-ylmethanol (299.3 g) and manganese dioxide (2.25 kg, type HMH, manufactured by Toso) were dispersed in t-butyl methyl ether (3.4 L) and the mixture was stirred at 10-30° C. for 6 hr. The reaction mixture was filtered and washed with t-butyl methyl ether (0.9 L). The solvent was evaporated under reduced pressure to give nearly pure 1-(4′-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbaldehyde (258.2 g, 87%) as pale-yellow white crystals.

Provenance & Evidence