Methanol → HCID 15390840, compound

Participants

Reaction Steps

4.5 g of potash then 10 ml of triethylamine are added to a suspension containing 10 g of 9,10-dimethoxy 8-(((4-methylphenyl)sulphonyl)oxy)2,3,5,6-tetrahydro-benz[e]azulen-4(1H)-one obtained as in Stage B and 100 ml of methanol. The reaction medium is heated under reflux for one hour, acidified by the addition of 20 ml of acetic acid then 20 ml of water is added. Extraction is carried out with dichloromethane, the extracts are washed with water, the solvent is evaporated off at 40° C. under reduced pressure and 5.7 g of expected product is collected.

Provenance & Evidence