1-Bromopropane → HCID 70149959, compound

HRID 990310Notes

Reaction equation

HRID 990310 reaction equation
[NH:1]1[CH:5]2[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]2[NH:3][C:2]1=[S:10].[Br:11][CH2:12][CH2:13][CH3:14]>C(O)C>[BrH:11].[CH2:12]([S:10][C:2]1[NH:3][CH:4]2[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]2[N:1]=1)[CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 78401-BromopropaneHCID 28238482-Hydroxy-5-nitrothiocarbanilide

Product 1

HCID 70149959HCID 70149959, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g of octahydro 2H-benzimidazol-2-thione and 1.3 ml of bromopropane in 20 ml of ethanol are heated under reflux until complete dissolution is obtained. The solvent is evaporated off under reduced pressure, the residue is taken up in a minimum amount of dichloromethane, isopropyl ether is added, the solvents are evaporated off under reduced pressure, the residue is recrystallized from isopropyl ether, the expected product is separated off and dried with a yield of 95%.

Workup

  1. temperatureunder reflux until complete dissolution
  2. customis obtained
  3. customThe solvent is evaporated off under reduced pressure
  4. additionis added
  5. customthe solvents are evaporated off under reduced pressure
  6. customthe residue is recrystallized from isopropyl ether
  7. customthe expected product is separated off
  8. customdried with a yield of 95%

Sources & evidence

ORD record
ord-d2747b8ff70b4a42b863385f2c5a540f
Source dataset
uspto-grants-2002_10
Patent number
US06459001B1

Reaction notes

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