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HRID9904

反应详情

EQUATION

反应方程式

HRID 9904 的结构方程式

REACTANTS

反应物

2
结构：CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21
HCID178418768

未命名化合物

结构：CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21
HCID178419004

未命名化合物

PRODUCTS

生成物

2
结构：NC1CCC(N)CC1
HCID18374

1,4-Diaminocyclohexane

C6H14N2

结构：CCn1cnc2c(Nc3cccc(Cl)c3)nc(Cl)nc21
HCID11001320

2-Chloro-N-(3-chlorophenyl)-9-ethyl-9H-purin-6-amine

C13H11Cl2N5

PROCEDURE

实验过程

Analogously to Example 1, 2-(trans-4-amino-cyclohexyl-amino)-6-(3-chloro-phenyl-amino)-9-ethyl-9H-purine; FAB-MS: (M+H)+=386; HPLC: tret (grad20/2)=8.47 minutes, and 2-(cis-4-amino-cyclohexyl-amino)-6-(3-chloro-phenyl-amino)-9-ethyl-9H-purine; FAB-MS: (M+H)+=386; HPLC: tret (grad20/2)=9.37 minutes are obtained from 308 mg (1.00 mmol) of 2-chloro-6-(3-chloro-phenyl-amino)-9-ethyl-9H-purine [described in Stage 1.2] and 3.26 g (28.6 mmol) of 1,4-diamino-cyclohexane (cis/trans mixture) after 25 h at 100° C. and purification by means of column chromatography.