HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 990572Generated: October 25, 2026
1-Bromo-3-chloropropane → n-[2-(3-Chloropropoxy)-5-nitrophenyl]acetamide
https://huagongshe.com/reaction/990572
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Acetamide, N-(2-hydroxy-5-nitrophenyl)- | HCID 3292867 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | n-[2-(3-Chloropropoxy)-5-nitrophenyl]acetamide | HCID 18415451 | — |
Reaction Steps
A mixture of 186.5 g (0.94 mol) of N—(2-hydroxy-5-nitrophenyl)acetamide and 142.7 g (1.03 mol) of potassium carbonate in 570 ml of dimethylformamide was heated to 30-35° C. with stirring; 444.0 g (2.82 mol) of 1-bromo-3-chloropropane were then added and heating was continued at 40° C. for 7 hours (orange-coloured suspension).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06461389B1 |
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| Source dataset | uspto-grants-2002_10 |
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| ORD ID | ord-1431f11f41c74938b6e443c9084a24fd |
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| Source note | uspto-grants-2002_10 |
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