1-Methylimidazole → HCID 178426614, compound

HRID 990574Notes

Reaction equation

HRID 990574 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([OH:13])[CH:7]=1)=[O:4].[CH3:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>C1(C)C=CC=CC=1>[Cl-:1].[OH:13][C:8]1[CH:7]=[C:6]([NH:5][C:3]([CH2:2][N+:17]2[CH:18]=[CH:19][N:15]([CH3:14])[CH:16]=2)=[O:4])[CH:11]=[CH:10][C:9]=1[CH3:12]

Participants

4

Reactant 2

HCID 13901-MethylimidazoleHCID 18415473HCID 18415473, compound

Product 1

HCID 178426614HCID 178426614, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

36.6 g (0.183 mol) of 2-chloro-N—(3-hydroxy-4-methylphenyl)acetamide and 29.2 ml (0.366 mol) of 1-methyl-1H-imidazole in 180 ml of toluene were refluxed for one and a half hours.

Sources & evidence

ORD record
ord-bbb35525b9c94c749467a4c3ce342125
Source dataset
uspto-grants-2002_10
Patent number
US06461389B1

Reaction notes

Loading…