4-Pyridineethanamine → 3-[[2,2-Difluoro-2-(2-pyridinyl)ethyl]amino]-6-methyl-2-oxo-N-[2-(4-pyridinyl)ethyl]-1(2H)-pyrazineacetamide

HRID 990713Notes

Reaction equation

[F:1][C:2]([F:23])([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH2:3][NH:4][C:5]1[C:6](=[O:16])[N:7]([CH2:12][C:13]([OH:15])=O)[C:8]([CH3:11])=[CH:9][N:10]=1.[NH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=1>>[F:23][C:2]([F:1])([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH2:3][NH:4][C:5]1[C:6](=[O:16])[N:7]([CH2:12][C:13]([NH:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[O:15])[C:8]([CH3:11])=[CH:9][N:10]=1

Participants

Reactant 2

HCID 832754-Pyridineethanamine

HCID 10892675HCID 10892675, compound

Product 1

HCID 101133853-[[2,2-Difluoro-2-(2-pyridinyl)ethyl]amino]-6-methyl-2-oxo-N-[2-(4-pyridinyl)ethyl]-1(2H)-pyrazineacetamide

Procedure

4-1 was prepared from [3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetic acid and 4-(2-aminoethyl)pyridine essentially according to the procedure of Example 1, Step K. It was characterized as the hydrochloride salt. Mass Spectrum: Found: (M+1) 429.2.

Sources & evidence

ORD record: ord-0f7b96b8995548e7a6fa45794dd3dcf4
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06462050B1

Reaction notes

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