HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tryptamine → 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tryptamine | HCID 1150 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperonal | HCID 8438 | — |
| Product | 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline | HCID 201172 | 62.7% |
Reaction Steps
This compound was prepared using the same procedure as for Intermediate 1 with tryptamine (20.0 g, 120 mmol), 3,4-methylenedioxybenzaldehyde (20.6 g, 1.1 eg.) and TFA (18 mL, 2 eq.) to give the title compound (22 g, 60%) as white crystals after recrystallization from ethanol (m.p.:178° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06462047B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-181f133350bd4547bb63ab7d1e28d9f5 |
| Source note | uspto-grants-2002_10 |