反应详情

To a solution of 2-amino-5-(3-hydroxyphenyl)pyrazine (89 mg) in pyridine (10 mL) was added under ice-cooling phenyl chloroformate (63 μL). The mixture was stirred for 1 hour and then poured into water (30 mL) and extracted with ethyl acetate (20 mL×3). The extract was washed with saturated saline solution and then dried over anhydrous Na2SO4. The concentration of the solvent left a crystal residue, which was washed with ethyl ether (10 mL) to give the subject compound (51 mg).

1. extractionextracted with ethyl acetate (20 mL×3)
2. washThe extract was washed with saturated saline solution
3. dry with materialdried over anhydrous Na2SO4
4. waitThe concentration of the solvent left a crystal residue, which
5. washwas washed with ethyl ether (10 mL)