HCID 13122716, compound → HCID 18416678, compound

HRID 990795Notes

Reaction equation

HRID 990795 reaction equation
Br[C:2]1[C:6]([C:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]=2)=[CH:5][S:4][CH:3]=1.[C:13](C1C(Br)=CSC=1)(=[O:15])[CH3:14]>>[C:13]([C:2]1[C:6]([C:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]=2)=[CH:5][S:4][CH:3]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 13122716HCID 13122716, compoundHCID 155616161-(4-Bromothiophen-3-yl)ethan-1-one

Product 1

HCID 18416678HCID 18416678, compoundYield 31%

Procedure

Prepared from 3-bromo-4-cyclohex-1-enyl-thiophene (See MacDowell; Jeffries J. Org. Chem., 1970, 35, 871-875 incorporated herein by reference), in 31% yield analogous to the procedure for the preparation of 4-acetyl-3-bromo-thiophene. 1H NMR (300 MHz, CDCl3) δ7.90(d, 1H, J=2.7 Hz), 6.97 (d, 1H, J=2.7 Hz), 5.66 (q, 1H, J=1.8 Hz), 2.49 (s, 3H), 2.15-2.19 (m, 4H), 1.64-1.79 (m, 4H).

Sources & evidence

ORD record
ord-9a2b7994b5d649f3b7e530b381144f6c
Source dataset
uspto-grants-2002_10
Patent number
US06462069B2

Reaction notes

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