Water → HCID 178516083, compound

HRID 990799Notes

Reaction equation

HRID 990799 reaction equation
[S:1]1[CH:5]=[C:4]([N:6]([C:14]2[CH:18]=[CH:17][NH:16][N:15]=2)[C:7]2[CH:12]=[CH:11][C:10](O)=[CH:9][CH:8]=2)[C:3]2[CH:19]=[CH:20][CH:21]=[CH:22][C:2]1=2.[OH2:23]>>[S:1]1[CH:5]=[C:4]([N:6]([C:14]2[CH:18]=[CH:17][NH:16][N:15]=2)[C:7]2[CH:12]=[C:11]([OH:23])[CH:10]=[CH:9][CH:8]=2)[C:3]2[CH:19]=[CH:20][CH:21]=[CH:22][C:2]1=2

Participants

3

Reactant 2

HCID 962WaterHCID 178516239HCID 178516239, compound

Product 1

HCID 178516083HCID 178516083, compoundYield 26%

Procedure

Prepared in 26% yield from (5-benzo[b]thiophen-3-yl)-1H-pyrazol-3-yl)-3-(methoxy-phenyl)-amine analogous to the procedure for 4-(benzo[b]thiophen-3-yl-1H-pyrazol-3-ylamino)-phenol [Example 2(b)]. 1H NMR (300 MHz, DMSO-d6) δ12.40 (s, 1H), 9.09 (s, 1H), 8.33 (s, 1H), 8.06 (d, 2 H, J=6.9 Hz), 7.98 (s. 1H), 7.42-7.51 (m, 2H), 6.96 (t, 1H, J=7.8 Hz), 6.92 (br s, 1H), 6.71 (br s, 1H), 6.26 (br s, 1H), 6.15 (d, 1H, J=7.5 Hz). Anal. (C17H13N3OS.0.33 H2O) C, H, N, S. Calculated C=65.17; H=4.39; N=13.41; S=10.23; found C=65.30; H=4.40; N=13.05; S=10.19.

Sources & evidence

ORD record
ord-67ad915d516d4a2995fea2bdb5703419
Source dataset
uspto-grants-2002_10
Patent number
US06462069B2

Reaction notes

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