Sodium Methoxide → HCID 18416655, compound

HRID 990816Notes

Reaction equation

HRID 990816 reaction equation
[C:1]([NH:4][CH:5]([CH3:10])[CH:6]=[C:7](Cl)Cl)(=[O:3])[CH3:2].[CH3:11][O-:12].[Na+]>CO>[CH3:2][C:1]1[O:3][C:6]([CH2:7][O:12][CH3:11])=[C:5]([CH3:10])[N:4]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18416647HCID 18416647, compound

Product 1

HCID 18416655HCID 18416655, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.8 g of 3-acetamido-1,1-dichlorobut-1-ene and 1,0 g of sodium methylate in 20 ml of methanol is heated at the boiling point under reflux for 24 hours. Thereafter, the methanol is distilled off, the residue is taken up in 5 ml of water and 30 ml of methylene chloride and the organic phase is separated off and distilled in vacuo. 0.9 g of 2,4-dimethyl-5-methoxymethyl-oxazole is obtained, boiling point 54° C./20 mbar.

Workup

  1. temperatureunder reflux for 24 hours
  2. distillationThereafter, the methanol is distilled off
  3. custom30 ml of methylene chloride and the organic phase is separated off
  4. distillationdistilled in vacuo

Sources & evidence

ORD record
ord-9bf9115c2bc24144a99d9451fe4e9b42
Source dataset
uspto-grants-2002_10
Patent number
US06462068B1

Reaction notes

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