1-(4-Fluorophenyl)-2-methylpropan-1-ol → 1-(4-Fluorophenyl)-2-methylpropan-1-one

HRID 990886Notes

Reaction equation

HRID 990886 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:12])[CH:9]([CH3:10])[CH3:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 104195641-(4-Fluorophenyl)-2-methylpropan-1-olHCID 131709961Jones' reagent

Product 1

HCID 27828291-(4-Fluorophenyl)-2-methylpropan-1-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 1-(4-Fluoro-phenyl)-2-methyl-propan-1-ol (1.6 g) in acetone (10 mL) at 0° C. is added Jones reagent (20 mL) with stirring. After 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol. Diethyl ether is added followed by anhydrous magnesium and the mixture is filtered and evaporated to give the product, a yellow oil (1.2 g).

Workup

  1. customAfter 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol
  2. additionDiethyl ether is added
  3. filtrationthe mixture is filtered
  4. customevaporated
  5. customto give the product

Sources & evidence

ORD record
ord-d979bb80d0e04ddf9255bb8fc83edada
Source dataset
uspto-grants-2002_10
Patent number
US06462055B2

Reaction notes

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