反应详情

To a solution of 3-bromobenzyl bromide (15.0 g, 60 mmol) in methanol-dimethoxyethane (DME) (30 ml+10 ml), sodium methylate (4.9 g, 90 mmol) was added under cooling with ice. The mixture was stirred for 1 hour at room temperature. The reaction mixture was poured into water and extracted with ether. The organic layer was washed by an aqueous saturated solution of sodium chloride and dried over magnesium sulfate. The solvent was distilled off to obtain the title compound ( 12.1 g) having the following physical data.

1. temperatureunder cooling with ice
2. extractionextracted with ether
3. washThe organic layer was washed by an aqueous saturated solution of sodium chloride
4. dry with materialdried over magnesium sulfate
5. distillationThe solvent was distilled off