HCID 16658841, compound → HCID 16659513, compound

Participants

Reaction Steps

This compound was prepared according to General Method 4 (EXAMPLE 1) from (3R)-3-ethyl-3,4-dihydro-7-nitro-4-(2,2,2-trifluoroethyl)-2H-1,4-benzoxazine (5.6 g, 19.3 mmol) and 10% Pd/C (cat.) in 60 mL ethyl acetate to afford 4.8 g (95%) of (3R)-7-amino-3,4-dihydro-3-ethyl-4-trifluoroethyl-2H-1,4benzoxazine as a tan solid, which was carried on directly to the next step.

Provenance & Evidence