m-Chloroperbenzoic acid → HCID 15959410, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-chloroperoxybenzoic acid (450 mg, 60% pure) in dichloromethane (30 ml) was added dropwise with stirring over 15 minutes to a solution of 3-phenyl-1H-[1]benzothieno[3,2-c]pyrazole (400 mg) in dichloromethane (50 ml) at 0-5° C. The mixture was stirred at 5-15° C. for 4 hours, then washed with water, dried and evaporated to give a solid which was purified by chromatography on silica using petroleum ether/ethyl acetate (1:3) as the mobile phase. Appropriate fractions were collected, combined and evaporated to give a solid which was triturated with ether, and filtered to give 3-phenyl-1H-[1]benzothieno[3,2-c]pyrazole 4-oxide, m.p. 222-224° C.

Provenance & Evidence