HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 4-(1,4-Dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-(1-Oxospiro[indan-2,2'-oxiran]-3'-yl)benzoic acid | HCID 18415923 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1,4-Dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid | HCID 18415847 | — |
Reaction Steps
4-(1-Oxospiro[indan-2,2′-oxiran]-3′-yl)benzoic acid from Example 7b (780 mg), methanol (50 ml), hydrazine hydrate (0.18 ml) and glacial acetic acid (6 drops) were boiled under reflux for 24 hours. The mixture was cooled in ice and filtered to give 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid, m.p. >320° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06462036B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-0bdea34b53e84a23825daca7849a9092 |
| Source note | uspto-grants-2002_10 |