Sodium Carbonate → HCID 136383554, compound

Participants

Reaction Steps

A mixture of 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzonitrile (730 mg, Example 65), hydroxylamine hydrochloride (0.4 g), sodium carbonate (0.8 g) and ethanol (30 ml) was boiled under reflux for about 16 hours. The solvent was removed under reduced pressure at about 50° C. and the residue stirred with water (70 ml). The mixture was extracted with ethyl acetate and the combined organic phases dried, filtered and evaporated to give a solid. The solid was purified by flash column chromatography on silica using ethyl acetate as eluant to give a solid which was washed with diethyl ether and dried to give 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzamide oxime, m.p.>300° C.

Provenance & Evidence