Triethylamine → N-[2-(Diethylamino)ethyl]-N'-[4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl]urea

Participants

Reaction Conditions

Reaction Steps

A suspension of of 3-(4-isocyanatophenyl)-1,4-dihydroindeno[1,2-c]pyrazole, 2 (75 mg, 0.274 mmol), Et3N (0.191 mL, 1.37 mmol), N,N-diethylethylenediamine (0.112 mL, 1.37 mmol) in toluene (3 mL) was heated to about 95° C., for about 3 hours. The white solid was filtered off and washed with EtOAc and dried under vacuum to afford 61 mg (57%) of pure product. LC/MS 390 (M+1); LC retention time 2.76 minutes.

Provenance & Evidence