4-Phenylbenzyl chloride → 3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)propionic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]([S:8]([C:11]1[N:12]([CH3:16])[CH:13]=[CH:14][N:15]=1)(=[O:10])=[O:9])([CH3:7])[CH3:6])[CH3:2].CN1C=CN=C1S.ClC[C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[CH:29][CH:28]=1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([CH3:7])([S:8]([C:11]1[N:12]([CH3:16])[CH:13]=[CH:14][N:15]=1)(=[O:10])=[O:9])[CH2:6][C:36]1[CH:37]=[CH:38][C:33]([C:30]2[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=2)=[CH:34][CH:35]=1)[CH3:2]Participants
4
Procedure
3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-methyl-(1-methyl-1H-imidazolesulfonyl)-propionic acid ethyl ester Prepared from (1-Methyl-2-mercapto imidazole and 2-bromo ethyl propionate) (3.0 g, 12.2 mmol) and 4- chloromethylbiphenyl (2.97 g, 15 mmol). Yield 5.0 g (99%); low melting solid; MS 413 (M+H)+.
Sources & evidence
- ORD record
- ord-4093fdde060b4cd2aa65f5c38bcace37
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06462073B2
Reaction notes
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