HCID 10981489, compound → HCID 11002348, compound

HRID 991092Notes

Reaction equation

HRID 991092 reaction equation
C([O:3][C:4]([C:6]1([S:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:11][CH2:10][N:9]([CH:12]([CH3:14])[CH3:13])[CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH:12]([N:9]1[CH2:10][CH2:11][C:6]([S:15]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=2)(=[O:17])=[O:16])([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1)([CH3:14])[CH3:13]

Participants

4

Reactant 1

HCID 10981489HCID 10981489, compound

Product 1

HCID 11002348HCID 11002348, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-Isopropyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-isopropyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (5.6 g, 15.2 mmol) dissolved in methanol (75 ml) and 10N NaOH (25 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 2.18 g (42%); white powder; mp 204° C.; MS: 341.9 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-d4e9b553d12a44c98e49cd6c2757c45b
Source dataset
uspto-grants-2002_10
Patent number
US06462073B2

Reaction notes

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