HCID 11056973, compound → HCID 11077878, compound

HRID 991093Notes

Reaction equation

HRID 991093 reaction equation
C([O:3][C:4]([C:6]1([S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH3:12][N:9]1[CH2:8][CH2:7][C:6]([S:13]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)(=[O:15])=[O:14])([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 11056973HCID 11056973, compound

Product 1

HCID 11077878HCID 11077878, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-Methyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-methyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (8.7 g, 25.6 mmol) dissolved in methanol (300 ml) and 10N NaOH (35 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 3.23 g (41%); white solid; mp 204° C.; MS: 313.9 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-d0aa5c56e8394846a607e99297e9a404
Source dataset
uspto-grants-2002_10
Patent number
US06462073B2

Reaction notes

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