Methanol → HCID 18416875, compound

HRID 991103Notes

Reaction equation

C([O:3][C:4]([C:6]1([S:21]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16](OC)=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-:35].[Na+].[CH3:37]O>>[CH2:31]([O:30][C:27]1[CH:28]=[CH:29][C:24]([S:21]([C:6]2([C:4]([OH:3])=[O:5])[CH2:7][CH2:8][N:9]([CH:12]([O:35][CH3:37])[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:10][CH2:11]2)(=[O:23])=[O:22])=[CH:25][CH:26]=1)[CH2:32][CH2:33][CH3:34]

Participants

Reactant 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 11762693HCID 11762693, compound

Product 1

HCID 18416875HCID 18416875, compound

Procedure

4-(4-n-Butoxy-benzenesulfonyl)1-(methoxy-benzyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4-Butoxy-benzenesulfonyl)-1-(4-methoxy-benzyl)piperidine-4- carboxylic acid ethyl ester (3.0 g, 6.1 mmol) dissolve in methanol (30 mL), 10N sodium hydroxide (10 mL), tetrahydrohydrofuiran (20 mL). The resulting reaction mixture was worked up as outlined in example 83. Yield 1.5 g (53%). white solid mp 207° C., MS: 462.5 (M+H)+.

Workup

customThe resulting reaction mixture

Sources & evidence

ORD record: ord-fece88cfab4646efa6e524d01bfe9a58
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06462073B2

Reaction notes

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