N-Benzylnormechlorethamine → 1-Benzyl-4-[4-(3-methyl-butoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	N-Benzylnormechlorethamine	HCID 5928	—
Reactant	[4-(3-Methyl-butoxy)phenylsulfonyl]-acetic acid ethyl ester	HCID 11088330	—
Product	1-Benzyl-4-[4-(3-methyl-butoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester	HCID 10906839	—

Reaction Steps

1-Benzyl-4-[4-(3-methyl-butoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method outlined in example 83 starting from [4-(3- methyl-butoxy)-phenylsulfonyl]-acetic acid ethyl ester (6.2 g, 20 mmol) and bis-(2-chloro-ethyl)-benzyl amine (6.44 g, 24 mmol). Yield 8 g (84%); yellow oil; MS: 474 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06462073B2
Source dataset	uspto-grants-2002_10
ORD ID	ord-177369290c1c4ca9ab7b359045ecac9d
Source note	uspto-grants-2002_10