huagongshe.com
HRID991151

反应详情

EQUATION

反应方程式

HRID 991151 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)C1C(=O)CC(C)(C)CC1=O
HCID519448

2-Acetyldimedone

C10H14O3

结构：CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1N
HCID10893359

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1NC(C)=C1C(=O)CC(C)(C)CC1=O
HCID178475056

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl amine (80 mg, 0.23 mmol) and 2-acetyldimedone (55 mg, 0.30 mmol) in MeOH (5 ml) was refluxed for 5 h. The reaction mixture was evaporated, the residue was purified by chromatography using CHCl3/MeOH 10:0.5 as the mobile phase, to give 2-Acetamido-3,4,6-tri-O-acetyl-1,2-dideoxy-1-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethylamino]-β-D-glucopyranose (19) (70 mg, 60%).

WORKUP

后处理

  1. temperaturewas refluxed for 5 h
  2. customThe reaction mixture was evaporated
  3. customthe residue was purified by chromatography