HCID 18417351, compound → HCID 18417358, compound

HRID 991165Notes

Reaction equation

HRID 991165 reaction equation
[N:1]([CH2:4][CH:5]([O:14][CH3:15])[CH:6]([OH:13])[CH:7]([OH:12])[C:8](=O)[CH2:9][OH:10])=[N+]=[N-].[H][H]>>[OH:10][CH2:9][CH:8]1[CH:7]([OH:12])[CH:6]([OH:13])[CH:5]([O:14][CH3:15])[CH2:4][NH:1]1

Participants

3

Reactant 2

HCID 18417351HCID 18417351, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18417358HCID 18417358, compound

Procedure

Then, the above 6-azido-5-methoxy-1,3,4-trihydroxy-2-hexanone intermediate is cyclized using reductive amination conditions with hydrogen and a catalyst for producing the 2-hydroxymethyl-3,4-dihydroxy-5-methoxypiperidine with the formula:

Sources & evidence

ORD record
ord-c2307affc9574a9c9f952ebe4afc6423
Source dataset
uspto-grants-2002_10
Patent number
US06462193B1

Reaction notes

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