反应详情

A solution of 3-azido-2(S)-methoxy-propanal diethyl acetal 25 (832 mg, 4.1 mmol) prepared in the same way as above as for compound 26 from the S-enatiomer was treated in the same manner as described for the R enantiomer. In this case rhamnulose-1-phosphate aldolase was added (0.5 mL, 80 units) and after usual monitoring and work-up, 380 mg (38%) of (3R,4S,5S)-6-azido-5-methoxy-1,3,4-trihydroxyhexan-2-one 27 were obtained. The NMR data were identical to those of 26.

1. additionwas treated in the same manner