反应详情

500.5 mg (1.64 mmol) (3.5-dimethylpyrazol-1-yl)-(9H-xanthen-9-yl)-methanone and 186.8 mg (1.64 mmol) 5-ethyl-[1,3,4]oxadiazol-2-ylamine were suspended in 1.5 ml DMF and stirred for 6 h at 130°. The reaction mixture was allowed to cool to room temperature and 5 ml of acetone were added. After stirring for 5 min, the product was filtered, washed with acetone and dried in vaccuo to yield 219.5 mg of 9H-xanthene-9-carboxylic acid (5-ethyl-[1,3,4]oxadiazol-2-yl)-amide as a white solid, m.p. 256-257° C. and MS: m/e=321.2 (M+) 48b) The 5-ethyl-[1,3,4]oxadiazol-2-ylamine used in the above reaction was obtained as follows:

1. stirringAfter stirring for 5 min
2. filtrationthe product was filtered
3. washwashed with acetone
4. customdried in vaccuo