(+/-)-cis-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-[4-(phenylmethyl)-1-piperazinyl]piperidine → (+/-)-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)piperidine

Participants

Reaction Steps

A mixture of compound 16 (8.4 g) in methanol (250 ml) was hydrogenated at 50° C. with palladium on activated carbon (10%) (2 g) as a catalyst. After uptake of H2, the catalyst was filtered off and the filtrate was evaporated; yielding 7 g (100%) of (±)-1-[3,5-bis(trifluoromethyl) benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)piperidine (compound 15).

Provenance & Evidence