Potassium Hydroxide → Alendronic Acid

HRID 991389Notes

Reaction equation

[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:9]([OH:12])([OH:11])=[O:10])([P:5]([OH:8])([OH:7])=[O:6])[OH:4].O.[OH-].[K+]>>[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:5]([OH:7])([OH:8])=[O:6])([P:9]([OH:12])([OH:11])=[O:10])[OH:4]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 15585620Alendronic acid monohydrate

Product 1

HCID 2088Alendronic Acid

Procedure

85.5 g of Alendronic Acid Monohydrate was dissolved in 700 ml of an aqueous solution containing 36 g of Potassium Hydroxide.

Sources & evidence

ORD record: ord-0c9852efe8e64b2c8dd57ca6445a4397
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06465017B1

Reaction notes

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