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Dicyclohexylcarbodiimide → [4(5-Undecyl-pyrimidin-2-yl)phenyl] 5-propyl-tetrahydrothiophene-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 5-Propyl-tetrahydrothiophene-2-carboxylic acid | HCID 18413606 | — |
| 反応物 | 4-(5-Undecylpyrimidin-2-yl)phenol | HCID 135619682 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [4(5-Undecyl-pyrimidin-2-yl)phenyl] 5-propyl-tetrahydrothiophene-2-carboxylate | HCID 15510032 | — |
反応手順
4.9 g of 4-(5-undecyl-pyrimidin-2-yl)phenol, 2.6 g of 5-propyl-tetrahydrothiophene-2-carboxylic acid (prepared as shown in Scheme 1) and 3.1 g of dicyclohexylcarbodiimide are stirred for 24 h in 50 ml of dichloromethane at room temperature. Filtration, removal of the dichloromethane by distillation, purification by chromatography (silica gel; dichloromethane/heptane) and recrystallization from acetonitrile affords the target compound as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06465060B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-dd3410bf48e347549e90408526209f76 |
| 出典メモ | uspto-grants-2002_10 |