Veratroyl chloride → HCID 9890246, compound

Participants

Reaction Conditions

Reaction Steps

3,4-Dimethoxybenzoyl chloride (1.55 g) was added to a stirred mixture of N-(3-amino-4-chlorophenyl)-2-nitrobenzamide (1.5 g) and pyridine (20 ml) and the mixture was stirred and heated to 80° C. for 16 hours. The mixture was cooled to ambient temperature and evaporated. The residue was partitioned between methylene chloride and 1N aqueous hydrochloric acid solution. The organic phase was washed with a saturated aqueous sodium bicarbonate solution and evaporated. The residue was triturated under ethyl acetate. The resultant solid was isolated, washed with a saturated aqueous sodium bicarbonate solution and dried under vacuum at 40° C. There was thus obtained the title compound (1.63 g);

Provenance & Evidence