1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 18413944, compound

Participants

Reaction Steps

To a suspension of Example 63 (190 mg) was added O-(tert-butyldimethylsilyl)-hydroxylamine (81 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (96 mg). After stirring overnight at room temperature ethyl acetate (100 mL) was added and the organic layer was washed with water (2×25 ml), saturated NaHCO3 (2×25 ml) and water (25 ml), dried over MgSO4, filtered and evaporated. The colourless oil was dissolved in dichloromethane (20 ml) and treated with 1.0 M HCl solution in ether (1.5 ml). Filtration afforded the title compound as a white solid (100 mg, 50%).

Provenance & Evidence