HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinecarboxaldehyde → 1-Isopropyl-6,7-methylenedioxy-4-(3-pyridyl)-3,4-dihydro-quinazolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | 1-(1,3-Benzodioxol-5-yl)-1-isopropylurea | HCID 100555 | — |
| Product | 1-Isopropyl-6,7-methylenedioxy-4-(3-pyridyl)-3,4-dihydro-quinazolin-2(1H)-one | HCID 23505650 | 36% |
Reaction Steps
This compound was synthesized from N-isopropyl-N-[3,4-(methylenedioxy)-phenyl]urea (238 mg) and 3-pyridinecarboxaldehyde (100 μL) by the procedure described in example 10 in 36% yield. mp: 172-174° C. 1H NMR (CDCl3): 8.58-8.56 (m, 3H), 7.63 (m, 1H), 7.29 (m, 2H), 6.70 (s, 1H), 6.34 (s, 1H), 5.94 (d, J=1.3, 1H), 5.92 (d, J=1.3, 1H), 5.33 (s, 1H), 5.9 (s, 1H), 4.41 (m, 1H), 1.53 (d, J=6.8, 3H), 1.50 (d, J=6.8, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465472B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-038e6946833944ae9a52f78eb0f4f0c3 |
| Source note | uspto-grants-2002_10 |