Acetic Acid → HCID 23505626, compound

Participants

Reaction Steps

3,4-(Ethylenedioxy)-2-amino-4,5-(methylenedioxy)benzophenone (15.0 g, 52.63 mmol) was dissolved in AcOH (250 mL) by heating. To this reaction mixture was added sodium cyanate (4.1 g, 63.16 mmol) and water (25 mL). The resulting mixture was then stirred at room temp. open to the air. After stirring for 18 h. excess water (120 mL) was added. The precipitate as collected by filtration. The precipitate was washed with water, and dried to give a 6,7-methylenedioxy-4-(3,4-ethylenedioxyphenyl)quinazolin-2(1H)-one as yellow solid (15.7 g); C16H10N2O5; mp >300° C. 1H NMR (DMSO) δ 11.80 (s, 1H), 7.11 (s, 1H), 7.08 (d, J=2.4 Hz, 1H), 6.98-7.02 (m, 2H), 6.79 (s, 1H), 6.14 (s, 2H), 4.30 (s, 4H).

Provenance & Evidence