4-[4-(4-fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2yl]benzonitrile → 4-[4-(4-Fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzoic acid

HRID 991541Notes

Reaction equation

HRID 991541 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:19]3[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[NH:11][C:12]=2C2C=CN=CC=2)=[CH:4][CH:3]=1.FC1C=CC(C2N=C(C3C=CC(C#N)=CC=3)NC=2[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([C:19]3[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:26][CH:27]=3)[NH:11][C:12]=2[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 98843484-[4-(4-fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2yl]benzonitrileHCID 110574684-[4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazol-2-yl]benzoic acid

Product 1

HCID 98636304-[4-(4-Fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzoic acid

Procedure

The title compound was prepared using the procedure in U.S. Pat. No. 5,656,644 (Example 9) to prepare 4- [4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazol-2yl]benzoic acid except using 4-[4-(4-fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2yl]benzonitrile. ESMS (M+H)+=360.1.

Sources & evidence

ORD record
ord-a44e6e2d03594edc893844bdc7395679
Source dataset
uspto-grants-2002_10
Patent number
US06465493B1

Reaction notes

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