HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(4-Fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzoic acid → Ethyl 4-[4-(4-fluorophenyl)-5-(2-pyridyl)-imidazol-2-yl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(4-Fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzoic acid | HCID 9863630 | — |
| Reactant | Sulphuric acid ethanol | HCID 73950302 | — |
| Product | Ethyl 4-[4-(4-fluorophenyl)-5-(2-pyridyl)-imidazol-2-yl]benzoate | HCID 9908258 | — |
Reaction Steps
Material from Example 3 was heated at reflux in a solution of ethanol/sulfuric acid for 18 h. The solution was concentrated to removed the ethanol and the resulting aqueous solution was extracted with chloroform to yield the title compound. ESMS (M+H)+=388.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465493B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-216ba2afd4c34d32a76a712130ebac31 |
| Source note | uspto-grants-2002_10 |