HCID 9799160, compound → HCID 9842943, compound

HRID 991546Notes

Reaction equation

HRID 991546 reaction equation
[O:1]1[C:5]2[CH:6]=[C:7]([C:10]3[N:11]=[C:12]([C:21]4[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=4)[NH:13][C:14]=3[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[O:29]1C2C=C(C3N=C(C4C=CC(C#N)=CC=4)N(O)C=3C3C=CC=CN=3)C=CC=2CC1>>[O:1]1[C:5]2[CH:6]=[C:7]([C:10]3[N:11]=[C:12]([C:21]4[CH:22]=[CH:23][C:24]([C:25]([NH2:26])=[O:29])=[CH:27][CH:28]=4)[NH:13][C:14]=3[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 9799160HCID 9799160, compoundHCID 18414581HCID 18414581, compound

Product 1

HCID 9842943HCID 9842943, compound

Procedure

Prepared according to the method of Example 14 from 4-[4-(2,3-dihydro-benzofuran-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]-benzonitrile which was prepared from 4-[4-(2,3-dihydro-benzofuran-6-yl)-1-hydroxy-5-pyridin-2-yl-1H-imidazol-2-yl]-benzonitrile according to the method of Example 2. 1H NMR (250 MHz, CDCl3) δ: 3.27 (2H, brt, J=8.5 Hz), 4.63 (2H, brt, J=8.5 Hz), 5.50-5.90 (1H, brs), 6.05-6.35 (1H, brs), 7.08-7.20 (3H, m), 7.18-7.30 (3H, m) 7.56 (2H, brs), 8.86 (2H, d, J=8.3 Hz), 8.04 (2H, d, J=8.3 Hz), 8.54 (1H, brd, J=4.5 Hz); m/z (ESMS): 383.5 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ccb35b77ae0e4fd8a8586e222e4a98e0
Source dataset
uspto-grants-2002_10
Patent number
US06465493B1

Reaction notes

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