HCID 18414578, compound → HCID 11501515, compound

Participants

Reaction Steps

N-(2-Benzo[1,3]dioxol-5-yl-2-oxo-1-pyridin-2-yl-ethyl)4-cyano-benzamide (0.1 g, 0.26 mmol) was dissolved in neat thionyl chloride (10 ml) and heated at reflux temperature for 2 hours. The cooled solution was cautiously added dropwise to a concentrated sodium hydroxide-ice mixture. The crude product was extracted into dichloromethane and purified using hexane-ethylacetate (1:1) as eluent to give the title compound (9 mg, 9%). 1H NMR (CDCl3) δ: 6.06 (2H, s), 6.84-6.99 (2H, m), 7.27-7.31 (1H, m), 7.86 (2H, d, J=7 Hz), 8.00 (2H, d, J=7 Hz), 8.04 (1H, s), 8.23 (1H, dd, J=7 and 1 Hz), 8.42 (1H, d, J=7 Hz), 8.65 (1H, dd, J=7 and 1 Hz); m/z (API) 368 (M+H+).

Provenance & Evidence