Oxalyl chloride → HCID 22394525, compound

Participants

Reaction Steps

4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)benzoic acid (379 mg; 0.98 mmol) was suspended in dry dichloromethane (20 ml) under argon and treated sequentially with oxalyl chloride (0.1 ml) then N,N-dimethylformamide (1 drop). The mixture was stirred at ambient temperature for 1 h. More oxalyl chloride (2×0.1 ml) was added at 1 h and 2 h and the mixture stirred at ambient temperature for 5 h. Volatiles were removed under reduced pressure to give the title compound as an orange powder: m/z (methyl ester; API): 400.3 (M+H)+.

Provenance & Evidence