Water → HCID 18414578, compound

Participants

Reaction Steps

2-Amino-1-benzo[1,3]dioxol-5-yl-2-pyridin-2-yl-ethanone dihydrochloride (1 g, 3 mmol) was added to a stirring solution of 4-cyano-benzoyl chloride (0.459 g, 3 mmol) in dichloromethane (10 ml). Triethylamine (2 ml, 14 mmol) was added dropwise and the reaction was stirred at ambient temperature for 18 hours. Water was (50 ml) added the organics were extracted into dichloromethane. Chromatographic purification using a dichloromethane solution of ammonia in methanol (0.5% c. ammonia: 4.5% methanol: 95% dichloromethane) yielded the title compound as a pale yellow oil (0.9 g, 76%); m/z (API) 386 (M+H+, 100%).

Provenance & Evidence