2-(2-Naphthoxy)ethanol → 2-Chloro-3-[2-(2-naphthyloxy)ethoxy]pyrazine

Participants

Reaction Conditions

Reaction Steps

Sodium hydride (55% dispersion in mineral oil; 44 mg, 1.0 mmol) was added to a mixture of 2-(2-naphthoxy)ethanol (188 mg, 1.00 mmol) and 2,3-dichloropyrazine (149 mg, 1.00 mmol) in dioxane (0.5 mL), and the reaction mixture was stirred at 40° C. for 15 h. The crude material was used directly in Step 2.

Provenance & Evidence