1-Ethylpiperazine → HCID 22036440, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and N-ethylpiperazine (221 mg, 1.93 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 138 mg (72%) of the title product. HRMS m/z calcd for C18H23ClN4O2 (M)+ 362.1510, found 362.1526. Anal. (C18H23ClN4O2) C, H, N.

Provenance & Evidence