HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → HCID 22036378, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-[(2-Bromopyridin-3-yl)oxy]ethan-1-ol | HCID 22036263 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22036378 | HCID 22036378 | 45% |
Reaction Steps
A mixture of the product obtained in Step 1 (2.33 g, 10.7 mmol) and NaOMe (0.634 mg, 11.8 mmol) in MeOH (50 mL) was refluxed overnight. The reaction mixture was filtered and concentrated. The residue was purified by column chromatography on silica, using CH2Cl2/MeOH/heptane (4:1:5) as eluent, to give 0.81 g (45%) of the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465467B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-000a0d7b546a49cc933a6a158c28495c |
| Source note | uspto-grants-2002_10 |