HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydrazinobenzoic acid → Deferasirox
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydrazinobenzoic acid | HCID 12089 | — |
| Reactant | 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | HCID 135685723 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Deferasirox | HCID 214348 | — |
Reaction Steps
5.0 g of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one and 3.5 g of 4-hydrazinobenzoic acid are boiled under reflux for 2 h in 75 ml of ethanol. The crystals precipitating on cooling are washed with ethanol. After drying, 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid remains as colorless crystals of m.p. 264-265 C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465504B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-e394166761394da59953e28a0bed6331 |
| Source note | uspto-grants-2002_10 |