Serinol → HCID 135817468, compound

HRID 991729Notes

Reaction equation

HRID 991729 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21](OCC)=[O:22])[N:9]=1.[NH2:26][CH:27]([CH2:30][OH:31])[CH2:28][OH:29]>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21]([NH:26][CH:27]([CH2:30][OH:31])[CH2:28][OH:29])=[O:22])[N:9]=1

Participants

4

Reactant 2

HCID 68294SerinolHCID 135914986Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate

Product 1

HCID 135817468HCID 135817468, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.0 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) and 2.0 g of 2-amino-1,3-propanediol are boiled under reflux for 3 h in 8 ml of ethanol. The crystals precipitating on cooling are recrystallized from isopropanol. After drying, 2-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2-hydroxy-1-hydroxymethylethyl)acetamide remains as colorless less crystals of m.p. 212-214° C.

Workup

  1. customThe crystals precipitating
  2. temperatureon cooling
  3. customare recrystallized from isopropanol
  4. customAfter drying

Sources & evidence

ORD record
ord-e0fb538806c94126a24a65dfb47d3aa7
Source dataset
uspto-grants-2002_10
Patent number
US06465504B1

Reaction notes

Loading…