HCID 43393146, compound → HCID 69311507, compound

HRID 991750Notes

Reaction equation

HRID 991750 reaction equation
C[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N:11]([S:13]([C:16]2[CH:21]=[CH:20][C:19](F)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH3:12])[C:3]=1[CH3:23].[OH:24][CH2:25][CH2:26][CH2:27][NH:28][C:29]([C:31]1[S:32][C:33]2[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=2[CH:35]=1)=[O:30]>>[S:32]1[C:33]2[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=2[CH:35]=[C:31]1[C:29]([NH:28][CH2:27][CH2:26][CH2:25][O:24][C:19]1[CH:20]=[CH:21][C:16]([S:13]([N:11]([CH3:12])[C:4]2[C:3]([CH3:23])=[CH:2][CH:10]=[CH:9][C:5]=2[C:6]([OH:8])=[O:7])(=[O:14])=[O:15])=[CH:17][CH:18]=1)=[O:30]

Participants

3

Reactant 2

HCID 43393146HCID 43393146, compoundHCID 69306956HCID 69306956, compound

Product 1

HCID 69311507HCID 69311507, compoundYield 19%

Procedure

The product of Example 2 (0.5 g, 1.58 mmol) was coupled to N-(3-hydroxypropyl)-1-benzothiophene-2-carboxamide (1.26 g, 5.37 mmol) using the procedure of Example 3 to provide 0.16 g (19% yield) of an off white solid. Electrospray Mass Spec: m/z 539.3 (M+H)+.

Workup

  1. customto provide 0.16 g (19% yield) of an off white solid

Sources & evidence

ORD record
ord-5e4d2ec11d654c39adb10b8a75767d05
Source dataset
uspto-grants-2002_10
Patent number
US06465508B1

Reaction notes

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