Trifluoroacetic acid → HCID 12969041, compound

Participants

Reaction Steps

This compound was prepared from tert-butyl (2 S)-3-[4-(benzyloxy)phenoxy]-2-hydroxypropyl{4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl}carbamate and trifluoroacetic acid in substantially the same manner as described in example 1, step e, with one modification, the product was isolated as the free base and recrystallized from methanol, tetrahydrofuran, hexanes to give a yellow foam solid (58% yield): mp 152° C.; MS m/e 508 (M+H)+; 1H NMR (DMSO-d6 300 MHz) δ2.68 (m, 2 H), 2.81 (m, 1 H), 2.88 (m, 4 H), 3.85 (m, 2 H), 4.00 (m, 1 H), 5.02 (s, 2 H), 5.45 (br, 1 H), 5.99 (d, 1 H), 6.59 (d, 2 H), 6.66 (d, 1 H), 6.84 (d, 2 H), 6.86 ( m, 2 H) 6.92 (m, 2 H), 7.28 (m, 5 H), 8.80 (br, 1 H);

Provenance & Evidence