4-Oxo-2,4,6,7-tetrahydropyrano[3,4-C]pyrrole-1-carbaldehyde → HCID 69708027, compound

HRID 991794Notes

Reaction equation

HRID 991794 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[O:16]=[C:17]1[C:22]2=[CH:23][NH:24][C:25]([CH:26]=O)=[C:21]2[CH2:20][CH2:19][O:18]1>>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[C:9]2=[CH:26][C:25]1[NH:24][CH:23]=[C:22]2[C:17](=[O:16])[O:18][CH2:19][CH2:20][C:21]=12)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 98340494-Oxo-2,4,6,7-tetrahydropyrano[3,4-C]pyrrole-1-carbaldehydeHCID 10176909N-methyl-2-oxoindoline-5-sulfonamide

Product 1

HCID 69708027HCID 69708027, compoundYield 79.1%

Procedure

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (0.2 g, 0.88 mmol) was condensed with 4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrole-1-carbaldehyde (1.2 eq, 0.18 g) to give 0.26 g (79%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-49f3d8c1721e471fa8c3f5e81c6bdfd7
Source dataset
uspto-grants-2002_10
Patent number
US06465507B2

Reaction notes

Loading…