反应详情

To a solution of disodium bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate (10.0 g, from example 3) in water (100 g) was added 0.5 g palladium on activated carbon (5 wt %). The mixture was transferred into a Parr reactor and was subjected to hydrogenation (50 psi, room temperature) for 8 hours. The activated carbon was filtered out, and the water was removed in vacuo at 75° C. The resulting product was dried and milled (m.p >300° C.). NMR and IR analyses were consistent with that of the expected structure.

1. filtrationThe activated carbon was filtered out
2. customthe water was removed in vacuo at 75° C
3. customThe resulting product was dried
4. custommilled (m.p >300° C.)